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Neural control of hepatic osmolytes and parenchymal cell hydration Haussinger DAnat Rec A Discov Mol Cell Evol Biol 2004[Sep]; 280 (1): 893-900Liver cell function is strongly influenced by cell hydration and osmolyte content via osmosensing and osmosignaling pathways. Electrical stimulation of hepatic nerves increases the hepatocellular hydration state via an alpha-adrenergic mechanism, promotes taurine release from parenchymal cells and myo-inositol release from hepatic stellate cells. Although changes in liver cell hydration and osmolyte content are known regulators of liver cell function, the functional relevance and integration of nerve-stimulation-dependent alterations of liver cell volume and osmolyte content in the overall hepatic response to towards signals from the nervous system remains to be established.|Animals[MESH]|Betaine/metabolism[MESH]|Electric Stimulation[MESH]|Hepatocytes/metabolism/physiology[MESH]|Inositol/metabolism[MESH]|Integrin beta Chains[MESH]|Ions/metabolism[MESH]|Liver/*cytology/*innervation/physiology[MESH]|Peripheral Nerves/*physiology[MESH]|Rats[MESH]|Signal Transduction/*physiology[MESH]|Taurine/metabolism[MESH]|Water-Electrolyte Balance/*physiology[MESH] |