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The nuclear envelope and human disease Muchir A; Worman HJPhysiology (Bethesda) 2004[Oct]; 19 (ä): 309-14Mutations in nuclear lamins A and C, intermediate filament proteins of the nuclear envelope, cause diseases affecting various tissues and the aging process. We review what is known about nuclear lamin function and the different diseases caused by mutations in lamins A and C and associated inner nuclear membrane proteins.|Animals[MESH]|Humans[MESH]|Lamins/*physiology[MESH]|Musculoskeletal Diseases/*physiopathology[MESH]|Nuclear Envelope/*physiology[MESH] |
