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Cytochrome P450 and the arachidonate cascade Capdevila JH; Falck JR; Estabrook RWFASEB J 1992[Jan]; 6 (2): 731-6Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.|Animals[MESH]|Arachidonic Acids/*metabolism[MESH]|Cytochrome P-450 CYP2J2[MESH]|Cytochrome P-450 Enzyme System/*metabolism[MESH]|Hydroxylation[MESH]|Kidney/physiology[MESH]|Membrane Lipids/physiology[MESH]|Membranes/physiology[MESH]|Mixed Function Oxygenases/metabolism[MESH]|Oxygenases/metabolism[MESH] |
