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Alpha-catenin: at the junction of intercellular adhesion and actin dynamics Kobielak A; Fuchs ENat Rev Mol Cell Biol 2004[Aug]; 5 (8): 614-25Alpha-catenin has often been considered to be a non-regulatory intercellular adhesion protein, in contrast to beta-catenin, which has well-documented dual roles in cell-cell adhesion and signal transduction. Recently, however, alpha-catenin has been found to be important not only in connecting the E-cadherin-beta-catenin complex to the actin cytoskeleton, but also in coordinating actin dynamics and inversely correlating cell adhesion with proliferation. As the number of alpha-catenin-interacting partners increases, intriguing new connections imply even more complex regulatory functions for this protein.|Actins/*physiology/ultrastructure[MESH]|Animals[MESH]|Cell Adhesion/*physiology[MESH]|Chromosome Mapping[MESH]|Cytoskeletal Proteins/chemistry/genetics/*physiology[MESH]|Gene Deletion[MESH]|Humans[MESH]|Models, Molecular[MESH]|Protein Conformation[MESH]|alpha Catenin[MESH] |
