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YidC family members are involved in the membrane insertion, lateral integration, folding, and assembly of membrane proteins Dalbey RE; Kuhn AJ Cell Biol 2004[Sep]; 166 (6): 769-74Members of the YidC family exist in all three domains of life, where they control the assembly of a large variety of membrane protein complexes that function as transporters, energy devices, or sensor proteins. Recent studies in bacteria have shown that YidC functions on its own as a membrane protein insertase independent of the Sec protein-conducting channel. YidC can also assist in the lateral integration and folding of membrane proteins that insert into the membrane via the Sec pathway.|*Protein Folding[MESH]|Animals[MESH]|Bacterial Proteins/chemistry/metabolism[MESH]|Escherichia coli Proteins/metabolism[MESH]|Humans[MESH]|Membrane Proteins/chemistry/*metabolism[MESH]|Membrane Transport Proteins/metabolism/*physiology[MESH]|Models, Biological[MESH]|Protein Precursors/*metabolism[MESH]|Substrate Specificity[MESH] |
