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Monotherapy in epilepsy: role of the newer antiepileptic drugs Vazquez BArch Neurol 2004[Sep]; 61 (9): 1361-5BACKGROUND: Monotherapy is the goal for pharmacological treatment of epilepsy. Well-controlled trials have established the efficacy of some of the newer antiepileptic drugs (AEDs) as monotherapy. OBJECTIVE: To review clinical data and expert opinions pertinent to the evaluation of most of the newer AEDs as monotherapy for epilepsy. DATA SOURCES: The MEDLINE database was searched for clinical trials using newer AEDs. Reference sections of review articles were manually searched to identify relevant studies not retrieved in MEDLINE. STUDY SELECTION: The resulting list of references was manually reviewed to identify monotherapy studies. RESULTS: Lamotrigine and oxcarbazepine demonstrated efficacy in randomized active-control trials in patients with newly diagnosed epilepsy and in substitution trials in patients refractory to conventional AEDs. CONCLUSION: Lamotrigine and oxcarbazepine are as effective as conventional AEDs at controlling partial seizures and are better tolerated.|Anticonvulsants/*administration & dosage[MESH]|Carbamazepine/administration & dosage/analogs & derivatives[MESH]|Clinical Trials as Topic[MESH]|Epilepsy/*drug therapy[MESH]|Humans[MESH]|Lamotrigine[MESH]|Oxcarbazepine[MESH]|Triazines/administration & dosage[MESH] |
