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 Preventing postpartum depression part I: a review of biological interventions Dennis CLCan J Psychiatry  2004[Jul]; 49 (7): 467-75OBJECTIVE: This paper critically reviews the literature to determine the current  state of scientific knowledge concerning the prevention of postpartum depression  (PPD) from a biological perspective. METHODS: The criteria used to evaluate the  interventions were derived from the standardized methodology developed by the  Canadian Task Force on Preventive Health Care. Databases searched for this review  include Medline, PubMed, Cinahl, PsycINFO, Embase, ProQuest, the Cochrane  Library, and the World Health Organization Reproductive Health Library. Studies  selected were peer-reviewed English-language articles published between January  1, 1966, and December 31, 2003. RESULTS: Seven studies that met criteria were  examined. These studies focused on evaluating the preventive effect of  antidepressant medication, estrogen and progesterone therapy, thyroid therapy,  docosahexanoic acid, and calcium supplementation. Although some of these  interventions have been examined rigorously for depression unrelated to  childbirth, methodological study limitations render intervention efficacy  equivocal for PPD; thus, there is limited strong evidence to guide practice or  policy recommendations. CONCLUSIONS: Despite the recent upsurge of interest in  this area, many questions remain unanswered, which has several implications for  research.|Adult[MESH]|Antidepressive Agents/therapeutic use[MESH]|Calcium/therapeutic use[MESH]|Depression, Postpartum/diagnosis/drug therapy/*prevention & control[MESH]|Diagnostic and Statistical Manual of Mental Disorders[MESH]|Docosahexaenoic Acids/therapeutic use[MESH]|Estrogens/therapeutic use[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Humans[MESH]|Progesterone/therapeutic use[MESH]|Randomized Controlled Trials as Topic[MESH]|Surveys and Questionnaires[MESH]
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