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lüll Thy-1: more than a mouse pan-T cell marker Haeryfar SM; Hoskin DWJ Immunol 2004[Sep]; 173 (6): 3581-8Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. T cell proliferation and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for Thy-1 in mouse T lymphocyte activation. However, a physiological ligand or counterreceptor for murine Thy-1 in the lymphoid compartment has not yet been identified. Thy-1 cross-linking, in the context of strong costimulatory signaling through CD28, results in an activating signal that can at least partially substitute for TCR signaling during mouse T cell activation. Remarkably, Thy-1 cross-linking also results in the potent costimulation of T cells activated through the TCR. This novel dual signaling capacity suggests a possible role for Thy-1 in the maintenance of T cell homeostasis in the absence of TCR triggering, as well as potentiating Ag-induced T cell responses.|Animals[MESH]|Antigens, Differentiation, T-Lymphocyte/*physiology[MESH]|Biomarkers/analysis[MESH]|Cell Differentiation/immunology[MESH]|Glycosylphosphatidylinositols/physiology[MESH]|Membrane Microdomains/chemistry/immunology[MESH]|Mice[MESH]|T-Lymphocyte Subsets/cytology/*immunology/metabolism[MESH]|Thy-1 Antigens/*analysis/metabolism/*physiology[MESH] |