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lüll Determination of the core of a minimal bacterial gene set Gil R; Silva FJ; Pereto J; Moya AMicrobiol Mol Biol Rev 2004[Sep]; 68 (3): 518-37, table of contentsThe availability of a large number of complete genome sequences raises the question of how many genes are essential for cellular life. Trying to reconstruct the core of the protein-coding gene set for a hypothetical minimal bacterial cell, we have performed a computational comparative analysis of eight bacterial genomes. Six of the analyzed genomes are very small due to a dramatic genome size reduction process, while the other two, corresponding to free-living relatives, are larger. The available data from several systematic experimental approaches to define all the essential genes in some completely sequenced bacterial genomes were also considered, and a reconstruction of a minimal metabolic machinery necessary to sustain life was carried out. The proposed minimal genome contains 206 protein-coding genes with all the genetic information necessary for self-maintenance and reproduction in the presence of a full complement of essential nutrients and in the absence of environmental stress. The main features of such a minimal gene set, as well as the metabolic functions that must be present in the hypothetical minimal cell, are discussed.|*Genes, Bacterial[MESH]|*Genome, Bacterial[MESH]|Bacteria/genetics/*growth & development/metabolism[MESH]|Bacterial Proteins/genetics/*metabolism[MESH]|Computational Biology[MESH] |