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CO-sensing mechanisms Roberts GP; Youn H; Kerby RLMicrobiol Mol Biol Rev 2004[Sep]; 68 (3): 453-73, table of contentsCarbon monoxide (CO) has long been known to have dramatic physiological effects on organisms ranging from bacteria to humans, but recently there have a number of suggestions that organisms might have specific sensors for CO. This article reviews the current evidence for a variety of proteins with demonstrated or potential CO-sensing ability. Particular emphasis is placed on the molecular description of CooA, a heme-containing CO sensor from Rhodospirillum rubrum, since its biological role as a CO sensor is clear and we have substantial insight into the basis of its sensing ability.|*Gene Expression Regulation[MESH]|*Signal Transduction[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Bacteria/metabolism[MESH]|Bacterial Proteins/chemistry/genetics/*metabolism[MESH]|Carbon Monoxide/analysis/*metabolism[MESH]|Eukaryotic Cells/physiology[MESH]|Hemeproteins/chemistry/genetics/*metabolism[MESH]|Humans[MESH]|Models, Molecular[MESH]|Molecular Sequence Data[MESH]|Trans-Activators/chemistry/genetics/*metabolism[MESH] |
