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lüll Innovations in attention-deficit/hyperactivity disorder pharmacotherapy: long-acting stimulant and nonstimulant treatments Stein MAAm J Manag Care 2004[Jul]; 10 (4 Suppl): S89-98This article reviews innovations in attentiondeficit/hyperactivity disorder (ADHD) pharmacotherapy and describes research on the newer, long-acting stimulant and nonstimulant treatments for ADHD. Results from peer-reviewed articles comparing the efficacy and safety of longer-acting methylphenidate or amphetamine-based stimulants and the nonstimulant atomoxetine are described. Longer-acting stimulants and nonstimulants provide increased clinical utility compared with short-acting stimulants. Efficacy and safety are similar to 2- or 3-times-a-day treatment with short-acting stimulants. Longer-acting stimulants and nonstimulants provide increased convenience and flexibility for treating youth with ADHD and show considerable promise. Direct head-to-head studies are needed to better inform clinical decision making and to identify moderators and mediators of differential response.|*Diffusion of Innovation[MESH]|Adolescent[MESH]|Attention Deficit Disorder with Hyperactivity/*drug therapy[MESH]|Central Nervous System Stimulants/administration & dosage/classification/*therapeutic use[MESH]|Child[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Treatment Outcome[MESH]|United States[MESH] |