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Regulation of protein kinases; controlling activity through activation segment conformation Nolen B; Taylor S; Ghosh GMol Cell 2004[Sep]; 15 (5): 661-75There are currently at least forty-six unique protein kinase crystal structures, twenty-four of which are available in an active state. Here we examine these structures using a structural bioinformatics approach to understand how the conformation of the activation segment controls kinase activity.|*Molecular Conformation[MESH]|Amino Acid Motifs/physiology[MESH]|Animals[MESH]|Catalytic Domain/physiology[MESH]|Computational Biology[MESH]|Humans[MESH]|Models, Molecular[MESH]|Phosphorylation[MESH]|Protein Kinases/*chemistry[MESH]|Protein Structure, Tertiary/physiology[MESH]|Sequence Homology, Amino Acid[MESH]|Structure-Activity Relationship[MESH] |
