Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Germinal tumor invasion and the role of the testicular stroma Diez-Torre A; Silvan U; De Wever O; Bruyneel E; Mareel M; Arechaga JInt J Dev Biol 2004[]; 48 (5-6): 545-57Testicular germ cell tumors (TGCTs) are the most frequent neoplasia among young people and their incidence has grown very quickly during recent decades in North America and Europe. Many studies have been carried out in order to elucidate the factors involved in the appearance and progression of these tumors. Little is known about the role of cancer cell-stroma crosstalk in TGCT invasive processes. Here, we review several factors which may be implicated in germ cell tumor progression, such as matrix metalloproteinases, insulin-like growth factor, transforming growth factor beta, the cadherin/catenin complex and integrins. Paradoxically, some of these molecules are also involved in the regulation of normal testicular function. Finally, we discuss prospects for future research on the role of the stroma in the progression and differentiation of male germ cell tumors.|*Neoplasm Invasiveness[MESH]|Animals[MESH]|Cell Adhesion[MESH]|Cell Line, Tumor[MESH]|Chick Embryo[MESH]|Cytoskeleton/metabolism[MESH]|Disease Progression[MESH]|Extracellular Matrix/metabolism[MESH]|Fibronectins/metabolism[MESH]|Growth Substances[MESH]|Humans[MESH]|Insulin-Like Growth Factor I/metabolism[MESH]|Laminin/metabolism[MESH]|Male[MESH]|Matrix Metalloproteinases/metabolism[MESH]|Mice[MESH]|Models, Biological[MESH]|Neoplasms, Germ Cell and Embryonal/*pathology[MESH]|Stromal Cells/pathology[MESH]|Testicular Diseases/pathology[MESH]|Testicular Neoplasms/*pathology[MESH]|Testis/pathology[MESH] |