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lüll Ghrelin: update on a novel hormonal system Korbonits M; Grossman ABEur J Endocrinol 2004[Aug]; 151 Suppl 1 (ä): S67-70Ghrelin is a peptide hormone secreted into the circulation from the stomach but also synthesised in a number of tissues, suggesting both endocrine and paracrine effects. These include: stimulation of GH, prolactin and ACTH secretion; an increase in appetite; a diabetogenic effect on carbohydrate metabolism; positive inotropic effects on heart; vasodilatation; and effects on cell proliferation. The possibility of chronic manipulation of the ghrelin system on body weight, growth and appetite remains an exciting new field of exploration.|*Appetite[MESH]|Amino Acid Sequence[MESH]|Body Weight/drug effects[MESH]|Ghrelin[MESH]|Growth Hormone/metabolism[MESH]|Growth/drug effects[MESH]|Humans[MESH]|Hypothalamo-Hypophyseal System/physiology[MESH]|Peptide Hormones/chemistry/*physiology[MESH]|Prader-Willi Syndrome/metabolism[MESH] |