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lüll Gene mutations and aneuploidy: the instability that causes cancer Woo RA; Poon RYCell Cycle 2004[Sep]; 3 (9): 1101-3Cancer cells have been characterized with activated mutant oncogenes and inactivated or deleted tumor suppressor genes. Cancer cells are also aneuploid, displaying a jumble of chromosomal anomalies including gain or loss of whole chromosomes or transposed chromosomal fragments. Whether mutation of specific genes or aneuploidy is more critical for tumorigenesis is very much a contentious issue. We recently showed that activated oncogenes induce oxidative damage that is exacerbated by conventional cell culture conditions. This "culture shock" or a loss of p53 function creates a precarious environment that permits oncogenes to induce rapid chromosomal instability and transformation. We found that mutant genes and aneuploidy were prerequisites and collaborators for neoplastic transformation.|*Aneuploidy[MESH]|Animals[MESH]|Cell Transformation, Neoplastic/genetics/*metabolism[MESH]|Chromosomal Instability/*genetics[MESH]|Gene Expression Regulation, Neoplastic/*genetics[MESH]|Humans[MESH]|Mutation/*genetics[MESH]|Oncogenes/genetics[MESH]|Oxidative Stress/genetics[MESH]|Tumor Suppressor Protein p53/genetics/metabolism[MESH] |