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Bone health New role for vitamin K?Ryan-Harshman M; Aldoori WCan Fam Physician 2004[Jul]; 50 (ä): 993-7OBJECTIVE: To assess growing evidence that vitamin K (phylloquinone) plays an important role in bone health and, subsequently, in prevention of osteoporotic fractures. QUALITY OF EVIDENCE: We searched MEDLINE from January 1972 to December 2002 using the key words vitamin K and bone health. We reviewed 30 articles that seemed relevant or had a human focus. All evidence can be categorized as level II. MAIN MESSAGE: Evidence suggests that dietary phylloquinone intake of <100 microg daily might not be optimal for bone health. Low intake of vitamin K could contribute to osteoporosis and subsequent fracture due to the undercarboxylation of osteocalcin. CONCLUSION: Family physicians need to be aware of the importance of encouraging adequate vitamin K intake, particularly among institutionalized elderly people, to prevent increased bone resorption. Further study is needed to determine the exact role of vitamin K in bone metabolism, and methods of assessing vitamin K requirements need to be standardized.|Aged[MESH]|Bone Resorption[MESH]|Clinical Trials as Topic[MESH]|Epidemiologic Studies[MESH]|Family Practice[MESH]|Female[MESH]|Fractures, Bone/etiology/prevention & control[MESH]|Humans[MESH]|Male[MESH]|Nutrition Policy[MESH]|Osteocalcin/metabolism[MESH]|Osteoporosis/complications/*prevention & control[MESH]|Vitamin K Deficiency/*complications/prevention & control[MESH]|Vitamin K/*pharmacology/*therapeutic use[MESH] |
