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lüll Stem cells and cancer; the polycomb connection Valk-Lingbeek ME; Bruggeman SW; van Lohuizen MCell 2004[Aug]; 118 (4): 409-18Proteins from the Polycomb group (PcG) are epigenetic chromatin modifiers involved in cancer development and also in the maintenance of embryonic and adult stem cells. The therapeutic potential of stem cells and the growing conviction that tumors contain stem cells highlights the importance of understanding the extrinsic and intrinsic circuitry controlling stem cell fate and their connections to cancer.|Animals[MESH]|Cell Differentiation[MESH]|Cell Line[MESH]|Chromatin/metabolism[MESH]|Cyclin-Dependent Kinase Inhibitor p16/metabolism[MESH]|Drosophila[MESH]|Embryo, Mammalian/cytology[MESH]|Embryo, Nonmammalian[MESH]|Hematopoietic Stem Cells/cytology/metabolism[MESH]|Histones/metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Neoplasms/metabolism/*pathology[MESH]|Neurons/metabolism[MESH]|Nuclear Proteins/metabolism[MESH]|Polycomb Repressive Complex 1[MESH]|Polycomb-Group Proteins[MESH]|Proto-Oncogene Proteins/metabolism[MESH]|Repressor Proteins/metabolism[MESH]|Stem Cells/*cytology/metabolism[MESH]|Up-Regulation[MESH] |