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  • Plattchen-Retentionstest Homburg: Drugmonitoring der Plattchenadhasivitat des von-Willebrand-Faktors
  • Wieding JU; Kostering H; Peine S; Wermes C; Mestres P; Wenzel E
  • Hamostaseologie 2004[Aug]; 24 (3): 217-20
  • Platelet plug formation is initiated by the process of platelet adhesion, mainly mediated by the von Wille-brand factor (VWF). Therefore, apart from established criteria the platelet adhesion property is a further criterion to determine VWF e. g. in diagnosis and treatment of von Willebrand disease (VWD). The new platelet retention test Homburg (RTH) is designed to close this gap. It is characterized by its non-thrombogenic filter with interconnecting pores, which retains platelets from blood when pressed through this filter due to the resulting shear stress. The RTH, in particular, proved to be highly sensitive in detecting the platelet adhesive property of VWF after its release from endogenous storage sites by desmopressin or infusion in VWD patients or its supplementation in vitro.
  • |Drug Monitoring/methods[MESH]
  • |Humans[MESH]
  • |Platelet Adhesiveness/*physiology[MESH]
  • |Platelet Function Tests/*methods[MESH]
  • |von Willebrand Diseases/*drug therapy[MESH]
  • |von Willebrand Factor/pharmacology/*therapeutic use[MESH]





  • *{{pmid15314709}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=15314709 Plattchen-Retentionstest Homburg: Drugmonitoring der Plattchenadhasivitat des von-Willebrand-Faktors ]</b> Hamostaseologie 2004; 24(3) ; 217-20 Wieding JU; Kostering H; Peine S; Wermes C; Mestres P; Wenzel E

        *15314709*

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    Hamostaseologie

    217 3.24 2004