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 Plattchen-Retentionstest Homburg: Drugmonitoring der Plattchenadhasivitat des  von-Willebrand-Faktors Wieding JU; Kostering H; Peine S; Wermes C; Mestres P; Wenzel EHamostaseologie  2004[Aug]; 24 (3): 217-20Platelet plug formation is initiated by the process of platelet adhesion, mainly  mediated by the von Wille-brand factor (VWF). Therefore, apart from established  criteria the platelet adhesion property is a further criterion to determine VWF  e. g. in diagnosis and treatment of von Willebrand disease (VWD). The new  platelet retention test Homburg (RTH) is designed to close this gap. It is  characterized by its non-thrombogenic filter with interconnecting pores, which  retains platelets from blood when pressed through this filter due to the  resulting shear stress. The RTH, in particular, proved to be highly sensitive in  detecting the platelet adhesive property of VWF after its release from endogenous  storage sites by desmopressin or infusion in VWD patients or its supplementation  in vitro.|Drug Monitoring/methods[MESH]|Humans[MESH]|Platelet Adhesiveness/*physiology[MESH]|Platelet Function Tests/*methods[MESH]|von Willebrand Diseases/*drug therapy[MESH]|von Willebrand Factor/pharmacology/*therapeutic use[MESH]
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