Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Relationship between idiopathic hypereosinophilic syndrome, eosinophilic leukemia, and systemic mastocytosis Bain BJAm J Hematol 2004[Sep]; 77 (1): 82-5Chronic eosinophilic leukemia is a neoplastic condition with persistent eosinophilia as the major hematological abnormality and with the eosinophils being part of the neoplastic clone. Some cases can be recognized by traditional hematological criteria, but many can be recognized only when a clonal cytogenetic or molecular genetic abnormality is demonstrated. A range of cytogenetic and molecular genetic abnormalities has been recognized, including both those seen in other myeloid malignancies (such as trisomy 8, monosomy 7, and 20q-) and those that are particularly linked to eosinophil differentiation (such as rearrangements of PDGFRB, FGFR1, and PDGFRA, the latter with formation of a FIP1L1-PDGFRA fusion gene). The discovery of the FIP1L1-PDGFRA fusion gene has led to the recognition that many patients who would previously have been regarded as having idiopathic hypereosinophilia actually have chronic eosinophilic leukemia. The same fusion gene has also been found in patients with hypereosinophilia and atypical bone marrow mast cells but whether this syndrome should be regarded as a variant of eosinophilic leukemia or as a variant of systemic mastocytosis remains to be established.|Benzamides[MESH]|Cytogenetic Analysis[MESH]|Diagnosis, Differential[MESH]|Humans[MESH]|Hypereosinophilic Syndrome/*diagnosis/genetics[MESH]|Imatinib Mesylate[MESH]|Mastocytosis, Systemic/*diagnosis/genetics[MESH]|Oncogene Proteins, Fusion[MESH]|Piperazines/therapeutic use[MESH]|Pyrimidines/therapeutic use[MESH]|Receptor, Platelet-Derived Growth Factor alpha/analysis/drug effects[MESH]|mRNA Cleavage and Polyadenylation Factors/analysis/drug effects[MESH] |