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Double minute chromosomes in monoblastic (M5) and myeloblastic (M2) acute myeloid leukemia: two case reports and a review of literature Thomas L; Stamberg J; Gojo I; Ning Y; Rapoport APAm J Hematol 2004[Sep]; 77 (1): 55-61Double minutes (dmin) are small, paired chromatin bodies that lack a centromere and represent a form of extrachromosomal gene amplification. Although they have been found in a variety of solid tumors, their presence in hematological malignancies, especially acute myeloid leukemia (AML), is rare. In addition, the presence of dmin may be a mechanism for upregulated oncogene expression and is generally associated with a poor prognosis. We describe two patients who had dmin at initial presentation of AML, including the first case of M5a with C-MYC amplification on dmin, and another case with C-MYC amplification as the only cytogenetic finding. We review here a total of 33 cases with dmin in AML. C-MYC was amplified by the dmin in 25 cases, while other putative oncogenes were amplified in the other 8.|*Chromosome Aberrations[MESH]|Adult[MESH]|Aged[MESH]|Chromatin[MESH]|Cytogenetic Analysis[MESH]|Gene Amplification[MESH]|Genes, myc/genetics[MESH]|Humans[MESH]|Leukemia, Monocytic, Acute/*genetics[MESH]|Leukemia, Myeloid, Acute/*genetics[MESH]|Male[MESH]|Oncogenes/genetics[MESH]|Particle Size[MESH]|Prognosis[MESH] |
