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lüll Label-free THz sensing of genetic sequences: towards THz biochips Haring Bolivar P; Nagel M; Richter F; Brucherseifer M; Kurz H; Bosserhoff A; Buttner RPhilos Trans A Math Phys Eng Sci 2004[Feb]; 362 (1815): 323-33; discussion 333-5THz-wave-based approaches for the label-free characterization of genetic material are described. Time-resolved THz spectroscopic analysis of genetic sequences (polynucleotides) demonstrate a distinct complex refractive index in the THz frequency range as a function of the binding state of the analysed DNA sequences. By monitoring THz signals, one can thus infer the binding state of oligo- and polynucleotides, enabling the label-free determination of the genetic composition of target polynucleotides by sensing their binding to known probe molecules. Here we review integrated THz sensing array developments exhibiting high sensitivity and single-base mutation detection capabilities. Recent achievements using functionalized biosensing arrays of high-Q resonators are illustrated.|Biosensing Techniques/instrumentation/*methods/trends[MESH]|DNA/*analysis/*chemistry/genetics[MESH]|Equipment Design[MESH]|Equipment Failure Analysis[MESH]|Infrared Rays[MESH]|Microwaves[MESH]|Oligonucleotide Array Sequence Analysis/instrumentation/*methods/trends[MESH]|Sequence Analysis, DNA/instrumentation/*methods/trends[MESH]|Spectrometry, Fluorescence/instrumentation/*methods/trends[MESH] |