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An introduction to the mechanics of DNA Travers AA; Thompson JMPhilos Trans A Math Phys Eng Sci 2004[Jul]; 362 (1820): 1265-79This article gives an overview of recent research on the mechanical properties and spatial deformations of the DNA molecule. Globally the molecule behaves like a uniform elastic rod, and its twisting and writhing govern its compaction and packaging within a cell. Meanwhile high mechanical stresses can induce structural transitions of DNA giving, for example, a phase diagram in the space of the applied tension and torque. Locally, the mechanical properties vary according to the local sequence organization. These variations play a vital role in the biological functioning of the molecule.|*Models, Molecular[MESH]|Base Sequence[MESH]|DNA-Binding Proteins/*chemistry/*ultrastructure[MESH]|DNA/*chemistry/*ultrastructure[MESH]|Elasticity[MESH]|Molecular Sequence Data[MESH]|Motion[MESH]|Nucleic Acid Conformation[MESH]|Nucleic Acid Denaturation[MESH]|Stress, Mechanical[MESH]|Structure-Activity Relationship[MESH]|Torque[MESH] |
