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lüll Ca2+ channels as integrators of G protein-mediated signaling in neurons Strock J; Diverse-Pierluissi MAMol Pharmacol 2004[Nov]; 66 (5): 1071-6The observations from Dunlap and Fischbach that transmitter-mediated shortening of the duration of action potentials could be caused by a decrease in calcium conductance led to numerous studies of the mechanisms of modulation of voltage-dependent calcium channels. Calcium channels are well known targets for inhibition by receptor-G protein pathways, and multiple forms of inhibition have been described. Inhibition of Ca(2+) channels can be mediated by G protein betagamma-subunits or by kinases, such as protein kinase C and tyrosine kinases. In the last few years, it has been shown that integration of G protein signaling can take place at the level of the calcium channel by regulation of the interaction of the channel pore-forming subunit with different cellular proteins.|Animals[MESH]|Calcium Channels/chemistry/*physiology[MESH]|Calcium/metabolism[MESH]|GTP-Binding Proteins/*physiology[MESH]|Humans[MESH]|Neurons/*physiology[MESH]|Protein Kinase C/metabolism[MESH]|Protein-Tyrosine Kinases/metabolism[MESH]|Receptors, G-Protein-Coupled/metabolism[MESH]|Signal Transduction/*physiology[MESH] |