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lüll Biology and therapeutic advances for pediatric osteosarcoma Marina N; Gebhardt M; Teot L; Gorlick ROncologist 2004[]; 9 (4): 422-41Osteosarcoma is the most common malignant bone tumor in children and adolescents. Survival for these patients was poor with the use of surgery and/or radiotherapy. The introduction of multi-agent chemotherapy dramatically improved the outcome for these patients and the majority of modern series report 3-year disease-free survival of 60%-70%. This paper describes current strategies for treating patients with osteosarcoma as well as review of the clinical features, radiologic and diagnostic work-up, and pathology. The authors review the state of the art management for patients with osteosarcoma in North America and Europe including the use of limb-salvage procedures and reconstruction as well as discuss the etiologic and biologic factors associated with tumor development. Therapy-related sequelae and future directions in the biology and therapy for these patients are also discussed.|*Pediatrics[MESH]|Bone Neoplasms/*diagnosis/pathology/*therapy[MESH]|Humans[MESH]|Neoplasm Staging[MESH]|Osteosarcoma/*diagnosis/pathology/*therapy[MESH]|Prognosis[MESH] |