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Current status and future prospects of array-based comparative genomic hybridisation Snijders AM; Pinkel D; Albertson DGBrief Funct Genomic Proteomic 2003[Apr]; 2 (1): 37-45The majority of human cancers as well as many developmental abnormalities harbour chromosomal imbalances, many of which result in the gain and/or loss of genomic material. Conventional comparative genomic hybridisation (CGH) has been used extensively to map DNA copy number changes to chromosomal positions. The introduction of microarray CGH provided a powerful tool to precisely detect and quantify genomic aberrations and map these directly onto the sequence of the human genome. In the past several years, a number of different approaches towards array-based CGH have been undertaken. This paper reviews these approaches and presents some of the recently-developed applications of this new technology in both research and clinical settings.|Chromosome Aberrations[MESH]|DNA, Neoplasm/analysis[MESH]|Gene Dosage[MESH]|Genetic Markers[MESH]|Humans[MESH]|In Situ Hybridization, Fluorescence[MESH]|Neoplasms/genetics/pathology[MESH]|Nucleic Acid Hybridization/*methods[MESH]|Oligonucleotide Array Sequence Analysis/*methods[MESH] |
