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Regulation of alternative pre-mRNA splicing Woodley L; Valcarcel JBrief Funct Genomic Proteomic 2002[Oct]; 1 (3): 266-77The first wave of bioinformatic studies that followed genome and complementary DNA sequencing projects revealed that alternative splicing of messenger RNA precursors (pre-mRNAs) contributes substantially to transcriptome complexity in higher eukaryotes. Together with the realisation of the impact of the process on cell differentiation, development and disease, these studies portray alternative splicing as a fundamental component of gene regulation. Both detailed mechanistic studies and genome-wide analyses will be necessary to unravel the molecular basis for cell type-specific splice site selection. This paper will highlight some recent progress and future challenges for functional genomics and bioinformatics in this rapidly developing area.|*Alternative Splicing[MESH]|RNA Precursors/*genetics[MESH]|RNA, Messenger/chemistry/*genetics[MESH] |
