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Baroreceptor reflex in heart failure Wang W; Zhu GQ; Gao L; Tan W; Qian ZMSheng Li Xue Bao 2004[Jun]; 56 (3): 269-81Congestive heart failure is a syndrome that is usually initiated by a reduction in pump function of the heart, i.e. a decrease in cardiac output. Initially, a reduction in cardiac output leads to unloading of baroreceptor reflex that, in turn, increases heart rate through vago-sympathetic mechanisms and total peripheral resistance via an increase in sympathetic outflow to vascular beds. In this review we are thinking on how baroreceptor reflex plays a role in the abnormal control of the circulation in heart failure. This review and our recent studies suggest that: (1) baroreceptor reflex is blunted in heart failure; (2) central angiotensin II and reactive oxygen species play an important role in blunted baroreceptor reflex; (3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.|Angiotensin II/metabolism[MESH]|Animals[MESH]|Baroreflex/*physiology[MESH]|Cardiac Output/physiology[MESH]|Chemoreceptor Cells/physiology[MESH]|Exercise/physiology[MESH]|Heart Failure/*physiopathology[MESH]|Humans[MESH]|Reactive Oxygen Species/metabolism[MESH]|Sympathetic Nervous System/physiology[MESH]|Vascular Resistance/physiology[MESH] |
