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 What is evidence-based medicine and why should I care?Hess DRRespir Care  2004[Jul]; 49 (7): 730-41The principles of evidence-based medicine provide the tools to incorporate the  best evidence into everyday practice. Evidence-based medicine is the integration  of individual clinical expertise with the best available research evidence from  systematic research and the patient's values and expectations. A hierarchy of  evidence can be used to assess the strength of evidence upon which clinical  decisions are made, with randomized studies at the top of the hierarchy. The  efficient approach to finding the best evidence is to identify a systematic  review or evidence-based clinical practice guidelines. Calculated metrics, such  as sensitivity, specificity, receiver-operating-characteristic curves, and  likelihood ratios, can be used to examine the evidence for a diagnostic test.  High-level studies of a therapy are prospective, randomized, blinded,  placebo-controlled, have a concealed allocation, have a parallel design, and  assess patient-important outcomes. Metrics used to assess the evidence for a  therapy include event rate, relative risk, relative risk reduction, absolute risk  reduction, number needed to treat, and odds ratio. Although not all tenets of  evidence-based medicine are universally accepted, the principles of  evidence-based medicine nonetheless provide a valuable approach to respiratory  care practice.|*Evidence-Based Medicine[MESH]|Humans[MESH]|Meta-Analysis as Topic[MESH]|Practice Patterns, Physicians'[MESH]|Respiratory Tract Diseases/*therapy[MESH]|United States[MESH]
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