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lüll Non-immune functions of MHC class I glycoproteins in normal and malignant cells Fishman D; Elhyany S; Segal SFolia Biol (Praha) 2004[]; 50 (2): 35-42MHC class I glycoproteins play a pivotal role in the regulation of immune responses by presenting antigenic peptides to cytotoxic T lymphocytes and by regulating cytolytic activities of natural killer cells. Cells originating in malignant tumours are often characterized by a profound immune escape phenotype. This phenotype is frequently associated with alterations in MHC class I-related antigen processing and presentation that enable tumours to escape immune surveillance. However, it now becomes clear that MHC class I molecules do not only provide a mechanistic framework for the presentation of antigenic peptides but, rather, possess broader biological functions due to their ability to regulate cell-to-cell communication and receptor-mediated trans-membrane signal transduction. In the present review we made an attempt to reevaluate the significance of an altered MHC class I phenotype for tumour progression in view of the current state of knowledge concerning the aforementioned non-immune functions performed by these membrane glycoproteins.|*Antigen Presentation[MESH]|*Cell Communication[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Glycoproteins/*immunology[MESH]|Histocompatibility Antigens Class I/*immunology[MESH]|Humans[MESH]|Immunologic Surveillance[MESH]|T-Lymphocytes, Cytotoxic/*metabolism[MESH]|Tumor Cells, Cultured[MESH] |