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lüll Regulation of the Borna disease virus polymerase complex by the viral nucleoprotein p38 isoform Brief Report Schneider U; Naegele M; Staeheli PArch Virol 2004[Jul]; 149 (7): 1409-14Borna disease virus (BDV) polymerase can be reconstituted by co-expression of the viral genes N, P and L. N codes for two proteins, p39 and p38, resulting from alternative translation initiation. Using a viral minireplicon system we observed that unlike p39, p38 was almost completely inactive when expressed with P and L alone. Since BDV polymerase requires a 10-20 fold excess of N protein over P for high activity, we determined whether p38 might serve as buffer that influences the viral N:P ratio. We demonstrate that p38 efficiently rescued BDV polymerase activity in cells expressing unfavorably high amounts of P.|Borna disease virus/*enzymology/physiology[MESH]|Codon, Initiator[MESH]|Gene Expression Regulation, Viral[MESH]|Genes, Viral[MESH]|Nucleoproteins/*genetics/*physiology[MESH]|Protein Biosynthesis[MESH]|Protein Isoforms/genetics/physiology[MESH]|RNA-Dependent RNA Polymerase/genetics/*metabolism[MESH]|Replicon[MESH]|Sequence Deletion[MESH]|Viral Proteins/genetics/*physiology[MESH]|Virus Replication[MESH] |