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Mesothelin: a new target for immunotherapy Hassan R; Bera T; Pastan IClin Cancer Res 2004[Jun]; 10 (12 Pt 1): 3937-42Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. The mesothelin gene encodes a precursor protein that is processed to yield the 40-kDa protein, mesothelin, attached to the cell membrane by a glycosylphosphatidyl inositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor. The biological function of mesothelin is not known. Mesothelin is a promising candidate for tumor-specific therapy, given its limited expression in normal tissues and high expression in several cancers. SS1(dsFv)PE38 is a recombinant anti-mesothelin immunotoxin that is undergoing clinical evaluation in patients with mesothelin-expressing tumors. There is evidence that mesothelin is an immunogenic protein and could be exploited as a therapeutic cancer vaccine. A soluble mesothelin variant has been identified and could be a useful tumor marker for malignant mesotheliomas.|Animals[MESH]|Antigens, Neoplasm[MESH]|Biomarkers, Tumor[MESH]|Clinical Trials as Topic[MESH]|GPI-Linked Proteins[MESH]|Glycosylphosphatidylinositols/chemistry[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Immunotherapy/*methods[MESH]|Immunotoxins/chemistry[MESH]|Megakaryocytes/chemistry[MESH]|Membrane Glycoproteins/*chemistry/genetics/*physiology[MESH]|Mesothelin[MESH]|Mice[MESH]|Mice, Nude[MESH]|Models, Chemical[MESH]|Neoplasms/metabolism[MESH]|Protein Structure, Tertiary[MESH]|Recombinant Proteins/chemistry[MESH] |
