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lüll Function of the c-Myc oncoprotein Kato GJ; Dang CVFASEB J 1992[Sep]; 6 (12): 3065-72The c-Myc protein, the product of the c-myc proto-oncogene, is a nuclear phosphoprotein with DNA binding properties. Deregulated c-myc expression participates in the development of experimentally induced tumors, and its expression appears to be abnormal in many naturally occurring malignancies. Although the precise molecular mechanism of c-Myc activity in oncogenesis and in normal cell proliferation is unknown, recent advances have uncovered a series of molecular and cellular properties of c-Myc. These properties include nuclear localization, transcriptional activation, oligomerization nonspecific and specific DNA binding. Recently, the c-Myc protein was found to heterodimerize with Max, a protein that cooperates with c-Myc to bind specifically to a core DNA sequence, CAC(G/A)TG. These characteristics suggest that c-Myc participates in the regulation of gene transcription in normal and neoplastic cells.|Animals[MESH]|Humans[MESH]|Phenotype[MESH]|Proto-Oncogene Mas[MESH]|Proto-Oncogene Proteins c-myc/genetics/*physiology[MESH] |