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An immunophenotypic comparison of metanephric metaplasia of Bowman capsular epithelium with metanephric adenoma, Wilms tumor, and renal development: a case report and review of the literature Fischer EG; Carney JA; Anderson SR; Klatt EC; Lager DJAm J Clin Pathol 2004[Jun]; 121 (6): 850-6Metanephric metaplasia of the parietal epithelium of the Bowman capsule is a rare pathologic finding of unknown pathogenesis that has occurred in patients with widespread malignant neoplasms of various types. We report this finding in a 25-year-old woman with partial expression of the Carney triad who died of a disseminated gastrointestinal stromal tumor, specifically a gastric stromal sarcoma. The metaplasia involved both kidneys diffusely. It originated in the parietal epithelium of the Bowman capsule, extended into the proximal tubules, and focally surrounded the glomeruli in a semicircular manner Immunohistochemical analysis revealed that the cells of metanephric metaplasia expressed the Wilms tumor gene product, bcl-2 protein, and CD57 and cytokeratin 7 and keratin AE1/AE3 focally, but not CD56. This immunophenotype parallels that of metanephric adenoma, Wilms tumor, and nephrogenic rests and overlaps with antigen expression in certain periods of renal development.|Adenoma/metabolism/*pathology[MESH]|Adult[MESH]|Epithelium/metabolism/pathology[MESH]|Female[MESH]|Gastrointestinal Neoplasms/pathology[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Immunophenotyping[MESH]|Kidney Neoplasms/metabolism/*pathology[MESH]|Kidney/growth & development[MESH]|Metaplasia/metabolism/pathology[MESH]|Neoplasms, Multiple Primary/*pathology[MESH]|Sarcoma/pathology[MESH]|Wilms Tumor/metabolism/*pathology[MESH] |
