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Caveolae and caveolins in the cardiovascular system Gratton JP; Bernatchez P; Sessa WCCirc Res 2004[Jun]; 94 (11): 1408-17Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many cellular processes, including transcytosis of macromolecules, cholesterol transport, and signal transduction. Recent insights into the physiological and pathophysiological roles of these organelles and the caveolins from genetically modified mice suggest that they may be profoundly important for postnatal cardiovascular function, including endothelial barrier function, regulation of nitric oxide synthesis, cholesterol metabolism, and cardiac function.|*Cardiovascular Physiological Phenomena[MESH]|Animals[MESH]|Biological Transport[MESH]|Caveolae/*physiology[MESH]|Caveolins/genetics/*physiology[MESH]|Cell Compartmentation[MESH]|Cells, Cultured/ultrastructure[MESH]|Cholesterol/metabolism[MESH]|Endothelial Cells/ultrastructure[MESH]|Endothelium, Vascular/cytology/physiology[MESH]|Humans[MESH]|Membrane Microdomains/physiology[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Muscle, Smooth, Vascular/physiology[MESH]|Myocardium/ultrastructure[MESH]|Nitric Oxide Synthase Type II[MESH]|Nitric Oxide Synthase Type III[MESH]|Nitric Oxide Synthase/physiology[MESH]|Nitric Oxide/physiology[MESH]|Phenotype[MESH]|Protein-Tyrosine Kinases/physiology[MESH]|Signal Transduction[MESH] |
