Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Pituitary carcinoma: a review of the literature Ragel BT; Couldwell WTNeurosurg Focus 2004[Apr]; 16 (4): E7Pituitary carcinomas, defined as distant metastases of a pituitary neoplasm, are rare; fewer than 140 reports exist in the English literature. The initial presenting pituitary tumor is usually a secreting, invasive macroadenoma, with adrenocorticotropic hormone (ACTH)--and prolactin (PRL)--secreting tumors being the most common. The latency period between the diagnosis of a pituitary tumor and the diagnosis of a pituitary carcinoma is 9.5 years for ACTH-producing lesions and 4.7 years for PRL-secreting tumors. Survival after documentation of metastatic disease is poor; 66% of patients die within 1 year. Treatment options include additional surgery, radiotherapy, and chemotherapy, all of which are associated with poor results. Future studies will focus on identifying those invasive pituitary tumors most likely to metastasize and treating them aggressively before they progress to pituitary carcinomas.|Adrenocorticotropic Hormone/metabolism[MESH]|Biomarkers, Tumor/analysis[MESH]|Carcinoma/*diagnosis/genetics/metabolism/secondary/*therapy[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Genes, p53[MESH]|Genes, ras/genetics[MESH]|Humans[MESH]|Pituitary Gland/pathology/ultrastructure[MESH]|Pituitary Neoplasms/*diagnosis/genetics/metabolism/*therapy[MESH]|Point Mutation[MESH]|Prolactin/metabolism[MESH] |