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Recent advances in the analysis of steroid hormones and related drugs Gorog SAnal Sci 2004[May]; 20 (5): 767-82The development during the last 15 years and the state-of-the-art in the analysis of bulk steroid hormone drugs and hormone-like structures and pharmaceutical formulations made thereof are summarized. Other steroids (sterols, bile acids, cardiac glycosides, vitamins D) as well as biological-clinical aspects and pharmacokinetic and metabolic studies are excluded from this review. The state-of-the-art is summarized based on comparisons of monographs in the latest editions of the European Pharmacopoeia, United States Pharmacopoeia and the Japanese Pharmacopoeia. This is followed by sections dealing with new developments in the methodology for the fields of spectroscopic and spectrophotometric, chromatographic, electrophoretic and hyphenated techniques as well electroanalytical methods. The review is terminated by two problem-oriented sections: examples on impurity and degradation profiling as well as enantiomeric analysis.|Chromatography[MESH]|Electrochemistry[MESH]|Electrophoresis[MESH]|Europe[MESH]|Hormones/*analysis[MESH]|Pharmacopoeias as Topic[MESH]|Spectrophotometry[MESH]|Steroids/*analysis[MESH] |
