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lüll The cell cycle and how it is steered by Kaposi s sarcoma-associated herpesvirus cyclin Verschuren EW; Jones N; Evan GIJ Gen Virol 2004[Jun]; 85 (Pt 6): 1347-1361A timely coordination of cellular DNA synthesis and division cycles is governed by the temporal and spatial activation of cyclin-dependent kinases (Cdks). The primary regulation of Cdk activation is through binding to partner cyclin proteins. Several gammaherpesviruses encode a viral homologue of cellular cyclin D, which may function to deregulate host cell cycle progression. One of these is encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) and is called K cyclin or viral cyclin (v-cyclin). v-Cyclin is expressed in most of the malignant cells that are associated with KSHV infection in humans, labelling v-cyclin as a putative viral oncogene. Here are described some of the major structural and functional properties of mammalian cyclin/Cdk complexes, some of which are phenocopied by v-cyclin. In addition, the molecular events leading to orderly progression through the G(1)/S and G/M cell cycle phases are reviewed. This molecular picture serves as a platform on which to explain v-cyclin-specific functional properties. Interesting but largely speculative issues concern the interplay between v-cyclin-mediated cell cycle deregulation and molecular progression of KSHV-associated neoplasms.|*Cell Cycle[MESH]|*Cell Cycle Proteins[MESH]|Animals[MESH]|Catalytic Domain[MESH]|Cyclin-Dependent Kinases[MESH]|Cyclins/*physiology[MESH]|DNA-Binding Proteins/physiology[MESH]|E2F Transcription Factors[MESH]|Enzyme Activation[MESH]|Herpesvirus 8, Human/*physiology[MESH]|Humans[MESH]|Mitosis[MESH]|Phosphorylation[MESH]|Retinoblastoma Protein/physiology[MESH]|Transcription Factors/physiology[MESH]|Viral Proteins[MESH] |