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lüll Aerosolized prostacyclins Siobal MRespir Care 2004[Jun]; 49 (6): 640-52Two prostacyclins (prostaglandin E(1) and prostaglandin I(2)) are potent vasodilators. Aerosolized prostacyclins reduce pulmonary artery pressure, improve right heart function, and increase arterial oxygenation by improving ventilation/perfusion matching. This report describes aerosolized prostacyclins and compares them to inhaled nitric oxide. I review the types of inhalable prostacyclins and their indications, evidence of efficacy, delivery, and adverse effects.|Administration, Inhalation[MESH]|Aerosols[MESH]|Alprostadil/administration & dosage[MESH]|Dose-Response Relationship, Drug[MESH]|Epoprostenol/administration & dosage[MESH]|Equipment Design[MESH]|Humans[MESH]|Hypertension, Pulmonary/drug therapy[MESH]|Iloprost/administration & dosage[MESH]|Nebulizers and Vaporizers[MESH]|Nitric Oxide/administration & dosage[MESH]|Prostaglandins I/*administration & dosage/adverse effects[MESH]|Respiratory Distress Syndrome/drug therapy[MESH]|Respiratory Therapy/instrumentation/*methods[MESH]|Treatment Outcome[MESH]|Vasodilator Agents/*administration & dosage/adverse effects[MESH]|Ventricular Dysfunction, Right/drug therapy[MESH] |