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lüll Inhaled bronchodilator administration during mechanical ventilation Duarte AGRespir Care 2004[Jun]; 49 (6): 623-34Inhaled bronchodilators are routinely administered to mechanically ventilated patients to relieve dyspnea and reverse bronchoconstriction. A lower percentage of the nominal dose reaches the lower respiratory tract in a mechanically ventilated patient than in a nonintubated subject, but attention to device selection, administration technique, dosing, and patient-ventilator interface can increase lower-respiratory-tract deposition in a mechanically ventilated patient. Assessing the airway response to bronchodilator by measuring airway resistance and intrinsic positive end-expiratory pressure helps guide dosing and timing of drug delivery. Selecting the optimal aerosol-generating device for a mechanically ventilated patient requires consideration of the ease, reliability, efficacy, safety, and cost of administration. With careful attention to administration technique, bronchodilator via metered-dose inhaler or nebulizer can be safe and effective with mechanically ventilated patients.|Administration, Inhalation[MESH]|Aerosols[MESH]|Bronchodilator Agents/*administration & dosage/chemistry[MESH]|Dose-Response Relationship, Drug[MESH]|Drug Monitoring/methods[MESH]|Equipment Design[MESH]|Heating[MESH]|Humans[MESH]|Humidity[MESH]|Intubation, Intratracheal/instrumentation[MESH]|Nebulizers and Vaporizers[MESH]|Patient Selection[MESH]|Respiration, Artificial/*instrumentation/*methods[MESH] |