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Plasminogen activator inhibitor type-1: its structure, biological activity and role in tumorigenesis (Review) Chorostowska-Wynimko J; Skrzypczak-Jankun E; Jankun JInt J Mol Med 2004[Jun]; 13 (6): 759-66Plasminogen activator inhibitor type-1 (PAI-1), is a unique member of serpin superfamily, the primary regulator of plasminogen activation and therefore essential factor regulating physiological thrombotic/fibrinolytic balance in vivo. Via interactions with integrins and extracellular matrix components it orchestrates also cell adhesion and migration. Therefore, PAI-1 is considered one of the key regulators of tumor invasion and metastasis, as well as cancer-related angiogenesis. This review summarizes recent findings on the structure and functional activity of the plasminogen activator inhibitor type-1, and current opinions on its role in tumorigenesis.|Animals[MESH]|Cell Adhesion/physiology[MESH]|Cell Movement/*physiology[MESH]|Cell Transformation, Neoplastic/*metabolism[MESH]|Extracellular Matrix/metabolism[MESH]|Fibrinolysis/*physiology[MESH]|Humans[MESH]|Integrins/metabolism[MESH]|Plasminogen Activator Inhibitor 1/*metabolism[MESH]|Plasminogen/metabolism[MESH]|Protein Structure, Tertiary[MESH]|Serpins/*metabolism[MESH] |
