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Interpretation erhohter D-Dimerkonzentration Ziegler T; Murzik M; Schau A; Winkler C; Funfstuck RHamostaseologie 2004[May]; 24 (2): 144-6BACKGROUND: The determination of D-dimer concentration is an essential part in the diagnostic procedure of thromboembolic diseases, e.g. deep vein thrombosis, pulmonary embolism. D-dimers are the products of fibrin hydrolysis with elevated levels in fibrinolytic processes. QUESTION: In the clinical practice problems exist in the interpretation of increased D-dimer concentrations, especially without thromboembolic disease. Before starting further expensive imaging diagnostics other reasons (i.e. pregnancy, neoplasma, systemic inflammatory disease, advanced arteriosclerosis) should be considered in differential diagnosis. CONCLUSION: The determination of the concentration of D-dimers is involved in the diagnostic strategy in thromboembolic diseases. However, this parameter is not suited for routine screening. Its high predictive-negative value is proved for the exclusion of thrombosis or pulmonary embolism in case of negative test result. Since a range of diseases and physiological conditions lead to increased D-dimer values, a positive D-dimer result does not verify the diagnosis of thromboembolism.|Antifibrinolytic Agents/*analysis[MESH]|Cardiovascular Diseases/blood[MESH]|Fibrin Fibrinogen Degradation Products/*analysis[MESH]|Fibrinolysis[MESH]|Humans[MESH]|Neoplasms/blood[MESH]|Thromboembolism/blood/*diagnosis/etiology/physiopathology[MESH] |
