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Molecular mechanisms of E2F-dependent activation and pRB-mediated repression Frolov MV; Dyson NJJ Cell Sci 2004[May]; 117 (Pt 11): 2173-81Alterations in transcription of genes regulated by members of the E2F family of transcription factors can be viewed as a measure of the ebb and flow in a constantly evolving battle between repressor and activator complexes. Various chromatin regulatory complexes have been linked to Rb/E2F proteins, and changes in histone modifications correlate with states of E2F-dependent transcription. E2F has traditionally been viewed in the context of cell-cycle control. However, several recent studies have revealed a new aspect of E2F function in which pRB/E2F-family proteins confer stable repression of transcription. Such repression is evident in both actively proliferating cells and in cells that have withdrawn from the cell cycle.|*Gene Silencing[MESH]|Acetyltransferases/metabolism[MESH]|Animals[MESH]|Cell Cycle Proteins/chemistry/classification/*metabolism[MESH]|DNA-Binding Proteins/chemistry/classification/*metabolism[MESH]|E2F Transcription Factors[MESH]|Histone Acetyltransferases[MESH]|Histone Deacetylases/metabolism[MESH]|Humans[MESH]|Repressor Proteins/*metabolism[MESH]|Retinoblastoma Protein/*metabolism[MESH]|Transcription Factors/chemistry/classification/*metabolism[MESH] |
