Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Biochemistry of transmembrane signaling mediated by trimeric G proteins Svoboda P; Teisinger J; Novotny J; Bourova L; Drmota T; Hejnova L; Moravcova Z; Lisy V; Rudajev V; Stohr J; Vokurkova A; Svandova I; Durchankova DPhysiol Res 2004[]; 53 Suppl 1 (ä): S141-52Many extracellular signals are at the cell surface received by specific receptors, which upon activation transduce information to the appropriate cellular effector molecules via trimeric G proteins. The G protein-mediated cascades ultimately lead to the highly refined regulation of systems such as sensory perception, cell growth, and hormonal regulation. Transmembrane signaling may be seriously deranged in various pathophysiological conditions. Over the last two decades the major experimental effort of our group has been devoted to better understanding the molecular mechanisms underlying transmembrane signaling regulated by G proteins and to the closely related process of desensitization of hormone response. This review provides general information about the basic principles of G protein-regulated transmembrane signaling as well as about our contribution to the current progress in the field.|*Signal Transduction[MESH]|Adipose Tissue, Brown/metabolism[MESH]|Adipose Tissue/metabolism[MESH]|Animals[MESH]|Brain/metabolism[MESH]|Caveolae/metabolism[MESH]|Cell Line[MESH]|Cells, Cultured[MESH]|GTP-Binding Protein Regulators/metabolism[MESH]|GTP-Binding Proteins/chemistry/*metabolism[MESH]|Hormones/metabolism[MESH]|Humans[MESH]|Myocardium/metabolism[MESH]|Neurotransmitter Agents/metabolism[MESH]|Receptors, Adrenergic, beta/metabolism[MESH]|Receptors, G-Protein-Coupled/*metabolism[MESH]|Sodium-Potassium-Exchanging ATPase/metabolism[MESH] |