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lüll Thematic review series: the pathogenesis of atherosclerosis An interpretive history of the cholesterol controversy: part I Steinberg DJ Lipid Res 2004[Sep]; 45 (9): 1583-93This is the first of a series of reviews of the controversy that swirled around the "lipid hypothesis" of atherosclerosis for so many years. Today, in the era of the statins, there is no longer any doubt about the value of decreasing blood cholesterol levels. In fact, "the lower the better" is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is worth telling for its own sake and because remembering it may help us avoid similar mistakes in the future. The history of this controversy is worth telling for its own sake and because remembering it may help us avoid similar mistakes in the future.|Animals[MESH]|Arteriosclerosis/blood/etiology/*history[MESH]|Biomedical Research/history[MESH]|Cholesterol/adverse effects/blood/*history[MESH]|History, 20th Century[MESH]|Humans[MESH]|Hyperlipidemias/complications/*history[MESH]|Lipoproteins/adverse effects/*history[MESH]|Male[MESH]|Models, Biological[MESH]|Rabbits[MESH] |