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lüll Mood disturbance before and after seizure surgery: a comparison of temporal and extratemporal resections Wrench J; Wilson SJ; Bladin PFEpilepsia 2004[May]; 45 (5): 534-43PURPOSE: Mood disturbance is a common comorbid condition of temporal lobe epilepsy before and after seizure surgery. Few studies have examined mood disturbance in patients undergoing resections outside the temporal lobe (extratemporal resections). This study aimed to compare the early, postoperative evolution of mood disturbance in temporal and extratemporal lobe epilepsy patients to examine the effect of site of surgical resection on mood outcome. METHODS: The study used a longitudinal design and was qualitative in nature. Sixty seizure surgery patients (43 temporal resections, 17 extratemporal resections) were assessed before surgery and at discharge, 1 month, and 3 months after surgery, by using the Austin CEP Interview. Psychosocial adjustment, psychiatric difficulties, including depression and anxiety, and seizure frequency were assessed. RESULTS: Before surgery, both temporal and extratemporal patients had significant psychiatric histories with similarly high rates of depression (33 and 53%, respectively) and anxiety (23 and 18%, respectively). After surgery, significantly more temporal patients were seizure free at each of the reviews compared with extratemporal patients. Temporal patients also reported significantly higher levels of depression (26%), anxiety (42%), and psychosocial adjustment difficulties (64%) at the 1-month review than did extratemporal patients. Mood disturbance was significantly associated with adjustment difficulties in both groups, but was not related to seizure outcome at any review period. CONCLUSIONS: A general increase in mood disturbance was evident after surgery, particularly in temporal resection patients at the 1-month review. Site of surgery and psychosocial adjustment showed significant associations with postoperative mood disturbance, supporting the role of both neurobiological and psychosocial factors in mood outcome.|Adaptation, Psychological[MESH]|Adult[MESH]|Anxiety Disorders/diagnosis/epidemiology[MESH]|Cerebral Cortex/*surgery[MESH]|Depressive Disorder/diagnosis/epidemiology[MESH]|Diagnostic and Statistical Manual of Mental Disorders[MESH]|Epilepsy, Complex Partial/*surgery[MESH]|Epilepsy, Temporal Lobe/*surgery[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Humans[MESH]|Longitudinal Studies[MESH]|Male[MESH]|Mood Disorders/diagnosis/*epidemiology[MESH]|Postoperative Complications/diagnosis/*epidemiology[MESH]|Preoperative Care[MESH]|Psychiatric Status Rating Scales[MESH]|Social Adjustment[MESH]|Temporal Lobe/*surgery[MESH]|Treatment Outcome[MESH] |