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PET tracers and radiochemistry Schlyer DJAnn Acad Med Singap 2004[Mar]; 33 (2): 146-54This paper provides a brief review of the radiochemistry of radiopharmaceuticals used in positron emission tomography (PET). It includes some history of PET, the basic formation of radionuclides in a cyclotron target, the processing of the precursor molecules into a useful PET radiotracer and the clinical significance and outlook for PET radiotracers. This review is based on a series of recent books and articles outlining the fundamental goals of PET and how radiochemistry plays a part in achieving these goals. It is also drawn from the literature that has been developed in PET over the last 30 years since PET became a research and valuable clinical tool. PET is a growing field and the clinical applications of the chemistry and technology have just begun to be explored. There is a great deal left to do in order to explore the full potential of PET in the clinic.|*Radioactive Tracers[MESH]|*Tomography, Emission-Computed[MESH]|Heart Diseases/diagnostic imaging[MESH]|Humans[MESH]|Neoplasms/diagnostic imaging/radiotherapy[MESH]|Radiopharmaceuticals/*chemical synthesis/therapeutic use[MESH] |
