Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Structural bases for the chemical regulation of Connexin43 channels Delmar M; Coombs W; Sorgen P; Duffy HS; Taffet SMCardiovasc Res 2004[May]; 62 (2): 268-75Connexins proteins associate with a variety of catalytic and non-catalytic molecules. Also, different domains of connexin can bind to each other, providing a mechanism for channel regulation. Here, we review some of these associations, placing particular emphasis on the intramolecular interactions that regulate Connexin43 (Cx43). We also describe some novel methods that allow for the characterization of protein-protein interactions such as those observed in the cardiac gap junction protein Connexin43. Overall, intra- and inter-molecular interactions may regulate gap junctions to filter the passage of molecular messages between cells at the appropriate time and between the appropriate cells. As a potential area for future investigations, we also speculate as to whether some of the inter-molecular interactions involving connexins lead to modifications in the function of the associated protein, rather than on the function of connexin itself.|Animals[MESH]|Cell Communication[MESH]|Cell Membrane Permeability[MESH]|Connexin 43/*chemistry/genetics/metabolism[MESH]|Gap Junctions/*metabolism[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Hydrogen-Ion Concentration[MESH]|Ion Channel Gating[MESH]|Myocardium/metabolism[MESH]|Protein Binding[MESH]|Protein Structure, Tertiary[MESH] |