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lüll Keeping fingers crossed: heterochromatin spreading through interdigitation of nucleosome arrays Grigoryev SAFEBS Lett 2004[Apr]; 564 (1-2): 4-8Interphase eukaryotic nuclei contain diffuse euchromatin and condensed heterochromatin. Current textbook models suggest that chromatin condensation occurs via accordion-type compaction of nucleosome zigzag chains. Recent studies have revealed several structural aspects that distinguish the highly compact state of condensed heterochromatin. These include an extensive lateral self-association of chromatin fibers, prominent nucleosome linker 'stems', and special protein factors that promote chromatin self-association. Here I review the molecular and structural determinants of chromatin compaction and discuss how heterochromatin spreading may be mediated by lateral self-association of zigzag nucleosome arrays.|*Chromatin Assembly and Disassembly[MESH]|Animals[MESH]|Heterochromatin/physiology/*ultrastructure[MESH]|Humans[MESH]|Models, Biological[MESH]|Nucleoproteins[MESH]|Nucleosomes/*ultrastructure[MESH] |