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lüll LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way He X; Semenov M; Tamai K; Zeng XDevelopment 2004[Apr]; 131 (8): 1663-77Wnt signaling through the canonical beta-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/beta-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular beta-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.|*Zebrafish Proteins[MESH]|Animals[MESH]|Cytoskeletal Proteins/*metabolism[MESH]|Drosophila Proteins/genetics/metabolism[MESH]|Drosophila/genetics/metabolism[MESH]|Humans[MESH]|LDL-Receptor Related Proteins/genetics/*metabolism[MESH]|Protein Structure, Tertiary[MESH]|Proto-Oncogene Proteins/*metabolism[MESH]|Receptors, Cell Surface/genetics/metabolism[MESH]|Signal Transduction/*physiology[MESH]|Trans-Activators/*metabolism[MESH]|Wnt Proteins[MESH]|beta Catenin[MESH] |