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Driven to autoimmunity: the nod mouse Gallegos AM; Bevan MJCell 2004[Apr]; 117 (2): 149-51In the lymphoid system, T cells respond to space or under-crowding by dividing to maintain their numbers. In this issue of Cell, evidence is provided that this homeostatic proliferation, coupled with excess production of a cytokine, IL-21, is a key factor in susceptibility to autoimmune diabetes.|Animals[MESH]|Cell Division/immunology[MESH]|Diabetes Mellitus, Type 1/*immunology/physiopathology[MESH]|Genetic Predisposition to Disease/*genetics[MESH]|Homeostasis/immunology[MESH]|Interleukin-21[MESH]|Interleukins/*biosynthesis/genetics[MESH]|Lymphopenia/genetics/immunology/physiopathology[MESH]|Mice[MESH]|Mice, Inbred NOD/genetics/*immunology[MESH]|T-Lymphocytes/*immunology[MESH] |
